I think this needs to be pinned for SampleTank users here as its a very important doc. It has saved me from issues many times. I have a heavy SampleTank user and I a have found, if you start to deviate and customize too far off from the default, strange things happen to your DAW. Its best to stick to the default paths they recommend. My theory, some of these paths are hard coded in some of the SampleTank instrument config files, and when you start changing stuff, they break or crash.
Just my 2 cents.