you are absolutely right it will change the sound depending on which interface you use, as well as what di box, what strings, what picks, everything changes what that tone is going to be. which is why you work at that tone until its what you want to use, not what you can make better later. mixing isn’t about making production choices(this guitar needs a different distortion, oh thats way too thin of a sound) those are production choices that go into what the song is supposed to sound like. In my humble opinion, when you are at the mixing stage, there should be no question as to what the song sound is, mixing is adding the salt and pepper, not changing from chicken to beef.
with amplitube and now tonex, the options are almost limitless on the tones that can be achieved, but if you are in the production stage of a workflow, time should be spent on getting everything right at the source, meaning all guitars tracked need to be meticuously customized down to the amount of space of between mic and speaker in the ampsim to find the right tone for that sound you want to hear. i could have 30 different guitar tracks in a song but each one will be absolutely detailed with a fine tooth comb, so much so that I usually freeze the track and move on. Later in the session, if i find that a particular guitar sound isn’t working, i’ll simply unfreeze in reaper and adjust the sound accordingly using that same di’d track as the modulator for the amp sim carrier. this does two things: 1. allows for easier mixing for myself becuase i’m not trying to fix everything later and just kicking the can down the road. 2. allows for me to easily collab/hire mixers and send them the tracks without a long worksheet of plugins that need to be used in order to get my “sound”.(did i mention i mix at unity and use automation for everything so the faders never move?)
I have both ztones(di and booster). I plug into ztone di. Balanced xlr goes to console if i have rented a space or a umc 1820 if i’m at my homestudio(line input engaged on interface) , link goes to to BOSS OCT-5 then out to ztone booster/buffer(the oct i think is technically a buffer, but i like the extra grit i can get with the boost knob for fuzz with -1 octave) and the unbalanced out goes to a peterson strobe tuner. On the DAW, if i dont have the hardware on hand at the rented space, i usually have a Black 76 plugin on my input fx so that i know i can get the fattest DI tone by dialing it in just right. If the guitar the plyaer is using is a baritone i usually cut it around 60hzand accentuate the top end with the EQ-81 (all of these T-racks6) this setup can get me 90% there with whatever amp sim that i use.
Over the years i have tested balanced xlr in vs line input vs no di but direct into inferface with inst button in, boosters, non boosters, and truthfully: You can get any tone you want out of any setup you have if you just take the time to adjust the chain to what you hear at default. Turn up the input gain on the plugin, turn it down if necessary, put a second tonex plugin after the original tonex plugin is only set to clean tone with the second being distorted, put a different tube screamer emulation before the amp sim whatever it takes to get the tone you want, there truly are no rules.
The last thing i want to do is have to call an artist after they have felt they completed the album/song and say “i really didn’t like that tone we used, can you come back and just record again?” that will cause a client to lose confidence in you in a heartbeat.
Over the last 20 years or so ive simply developed a workflow that works for my situation and clients. It may not be for everyone, but it works for me.