For home-recording etc., I'd firstly say what everyone else says: know your speakers/headphones and know your room. And, yes, having an acoustically treated room is ideal if you are using speakers -- though I question whether this is realistic for the majority of AmpliTube users who are probably not actually operating a semi-pro -- let alone pro -- studio.
For my part, I've used the same AKG K240 MkII (semi-open-backed) headphones for more than a decade. I play guitar and bass through them, I mix my recording projects on them, I listen to music and have video conferences with them .... So, I feel like I know them reasonably well.
Then, for the last few years -- for when I'm not using headphones -- I've also used a set of IKM's iLoud Micro Speakers just sitting on my desktop, flanking my monitor. One could easily argue that they should be better isolated from the desktop surface than their built-in rubberized feet make them, and certainly one could argue that my room (which is principally a home office) should be treated (though it definitely isn't) ....
But if I want to just play through my iLoud Micros, it sounds fine. And if I want to play through my headphones, that also sounds fine. And for mixing, I just go back and forth between my headphones and iLoud Micros -- and the car stereo!
-- and do the best I can (which I think is not
too bad for a total amateur like myself
).
Of course, one can spend just about as much on either headphones or speakers as one wants. The sky -- and the number of internal organs you have to sell -- are the limit!
But certainly if you are playing through or mixing on headphones (which effectively eliminates the room), the most important thing is probably that you know those headphones and what the music you like sounds like in those headphones.