I was having a problem with Amplitube 5.5.4 going south about every 2-3 days on my Win 10 box. Presets would start to sound really bad until the point of being unusable and I couldn't figure out why.
Found out the problem was with the Axe I/O SOLO all along NOT Amplitube 5.5.4. If you have a newer Windows computer you have to turn on EXP in the BIOS. This if disabled continues to provide USB power to devices so you can still charge USB devices with your computer shut down. This will leave your Axe I/O SOLO powered on indefinitely which will eventually corrupt the cached data from the Amplitube app stored in the Axe. This will not be a problem on MACs or with the non SOLO version of the Axe as it has it's own power switch. There is no workaround and this is repeatable.