It depends on the size of your room! At home, I prefer studio monitors.
AmpliTube comes out in stereo. If you use a single wedge monitor, FRFR etc. both sides of signal get summed which causes the top end to get muddy as they phase each other out.
If you get a pair of IK Multimedia iLoud Micro Monitors they are very big sounding particularly for their diminutive footprint.
On stage, I use a mono set up for monitoring and this meant that I had to treat the sound to get it to work better in mono. Lately however, I've got a pair of Headrush speakers. They're not flat enough for my liking so right now I still have to apply some EQ before the signal hits them but I'm getting closer at each rehearsal. This is something you'll need to do with any such speaker whether you've two or one.
Gettting an amp in the room sound is a bit of an EQ trick too.
Try this:
Use one type of microphone per cab, not two as this could create phasing issues.
Try use the cab room ambience
If you don't have the EQ-81 rack EQ in your version of AmpliTube - GET IT! Set the Low Mid dial to boost around 350k and it will help make the speakers sound more amp in the room.
Hope that helps! I built a live rig out of AmpliTube and I talk about how I got around these issues in this video:
https://www.youtube.com/watch?v=aOZBkt5s51U