Hi!
I am having random problem with AXE IO unit using USB3 connection under Windows10. It may work seamlessly for a while, but after restarting the system it might loose stereo output or wont be able to work at all (no sound, cant connect ASIO). All is resolved when connecting AXE IO into USB2 port which luckily I have. It immediately connects and is working as expected. If you continue to change different USB3 ports it wont work. Just until you connect it to the USB2 port. A bit annoying, but at least it is resolvable.
Threadripper system with x399
Thought I will write about this so it might help somebody else.