Hey, sorry to hear you are having issues.
In my learning curve since purchasing the product there's a few relevant things here I will share.
1. Check the phantom switch. If you're not actually using a mic, it will mess with the connection. Not sure if that's expected, but kind of makes sense I guess? (iow - make sure its not pressed in and is 'depressed'
)
2. Not being a super iOS, apple person and over a quarter century of being a pc person, realized I had to learn some 'common' behavior and expectations whereas apples and iOS devices, adapters and cables go. They are of such good quality, that anything else doesn't count.
At the signal level, there are a few things - if you plug your mini-din in AFTER the other end is in the iPad, I am not sure if it will detect and switch to DIGITAL AUDIO automatically. In fact, I almost always have to unplug the lightning side and re-plug it just to refresh the connection. I think this is normal apple behavior though, I've experience similar stuff with their chargers and adapters. USB end first, then the last part is to your iOS device. Now whether Amplitube and your rig need to be on and powered (and not in standby) may also have something to do with aforementioned.... behaviors.
3. Recently, owning a Boss K2 Katana, I realized the more optimal setup was taking full advantage of its Power Amp in on the back, instead of basically doubling pre-amps (and trippling in the case I am playing a guitar with active pickups)..... so the K2 can easily become just a host, powered speaker and the virtual or model amp heads are doing all the heavy work alone - as they should. I'm getting off track > At some point, I almost went crazy, because the power of the sound would cut drastically, like in the middle of a song and then when I'd pause it - I'd notice that it would kick back in. It was extremely intermittent and seemed related to the overall acoustic sound level in my room. It was. **** quality patch cable, one of those jobbies when you turn it while plugged in- you hear crackling. Anyway - check for that too. Don't skimp on cables. Make sure you get the best ones you can afford - shop around of course, because their are affordable and quality ones to be had.
Otherwise, maybe this is something else though, since we don't have the exact same setup.
Hope this can help check off anything you may have missed in your troubleshooting. Good luck and let us know how things go.
Ps. I do not work for ik, and tbh - TWICE was about 99% sure I was going to return this thing... and then.... a lot of things came together in a short time span and I was able to iron things out. Now? I don't want to use anything else. Well worth it for a home studio,jam solution.