I have an odd issue. I've been using Axe I/O and Amplitube 4 for a couple years. When I first set it up I could never get it to connect properly to my amp. I've read the user manual, and searched extensively online, and from my understanding the setup should be:
1.) AMP OUT of the AXE I/O to the INPUT of amplifier
2.) Connect guitar to AXE I/O Instrument inputs 1 or 2
I have never been able to get this to work. But, it does work when I use the HEADPHONE jack from the Axe I/O to my amplifier input, instead of AMP OUT. But the problem is I get my guitars clean sound in addition to whatever pedal setup in Amplitube. Its never really been an issue until recently I've been toying with more fuzz and distortion, and you can really hear the "clean" sound under it so it sounds like 2 guitars playing. I've toyed with this so much and it was so frustrating I just gave up and lived with it but now I have some time to try and fix it. Here are my Axe I/O and Amplitube settings. https://imgur.com/a/ZOVDVKS
If anyone has a moment to help me get this set up with the proper AMP OUT would be appreciated!