I finally got it and... this can't be how this is supposed to work.
First issue:
In the CONTROLLER window, I'm unable to change (or retain) anything. ALL the CC numbers are the same. I can change the first one (Data Knob) by dragging up or down, but then when I settle on a number....say 22.... ALL the other CC#'s change to 22. It doesn't matter what number I choose, they all change to the same number. If I try to change any of the other 3, it flashes a random number and then always goes back to the number that's in the Date Knob CC#. It makes the preset knob useless in Amplitube because I can't select anything (because it needs the Date Push button to be set at 23). And then in Amplitube, sometimes the Preset knob opens the preset menu, but most of the time it doesn't. It makes no sense to me. And right clicking in the window to reset it doesn't change anything, they still show the same numbers.
Second Issue:
I need to reset the External Controller 2 to "Single Switch" every time I open it. It always defaults to "Double Switch".
Third Issue:
Everytime my computer goes to sleep I lose the USB connection light. Audio still seems to play, but it only comes back if I hit the power button on and off. I really hope I don't need to turn it on and off everytime I sit down at the computer.
These issues can't be how this is supposed to work. I'm on a Macbook Pro (2019 Intel) and Big Sur 11.5. I've deleted the control panel app a few times (using Clean My Mac so I get the leftovers), restarted after each try, and the problems are still there.