If you have latency in your DAW while playing guitar through the AmpliTube5 vst/vst3/au plugin it is helpful to reduce the Requested Block Size. Instead of listening for crackling and popping to see if you've gone too low, Reaper as an option where you can right-click on the Transport bar and select
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Flash transport yellow on possible audio device underrun
- I have found this rather ugly feedback really helpful when trying to minimize latency. You can go down to where you first see the yellow flash. Then switch to dual amp paths back to one, watch the CPU drop and the yellow flashing will likely stop, and you'll have found the minimal usuable block size.