Using a TC Helicon, I had severe latency issues, not able to play backing tracks or any other audio (YouTube, Windows Player) while Amplitube was running. And, overall crap sound quality. No adjustment to sample rate, I/O, of buffer helped. GO Mobile does not use an ASIO driver.
Kicked the TC Helicon to the curb and used a Focusright Scarlett Solo.
The Scarlett was great - no latency, excellent sound quality, and can play multiple sources while running Amplitube.