The best way to explain is to talk about the differences between AmpliTube and TONEX. This is from another post:
AmpliTube and TONEX are two different products using different technologies: AmpliTube is made using analog modeling technology while TONEX uses a new technology called AI machine modeling (
https://www.amplitube.com/ai ). While analog modeling simulates the behavior of the whole circuit of the amp - with all the knobs, switches, buttons and their interactions - AI machine modeling gives an ultra-realistic simulation of the rig with a specific knob settings. So it's not that one technology is "better" than the other, it depends of what the final user's needs are: full editing and customization versus accuracy in getting a specific sound. Using them together gives of course the best of both worlds and a super-powerful amp-sim system.
The two products are also different because AmpliTube can simulate the entire set up used in guitar recording (multiple serial and parallel rigs combining amps, all type of stomp effects, post effects, cabinets and microphones, etc.. with full editing down to the single gear), while TONEX is dedicated to simulates just amp, cabinets and certain type of pedals (distortions, overdrive, fuzz, EQ, boost) in each of their combinations. However TONEX can be used inside AmpliTube, as a sub-system of amps and pedals, again to have the best of both worlds.